Increased ROS production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin resistant human skeletal muscle
نویسندگان
چکیده
1 Center for Metabolic Biology, Arizona State University, Tempe, Arizona; 2 School of Life Sciences, Arizona State University, Tempe, Arizona; 3 Department of Kinesiology, Arizona State University, Tempe, Arizona; 4 Harrington Department of Bioengineering, Arizona State University, Tempe, Arizona; 5 Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Odense, Denmark; 6 Department of Medicine, Mayo Clinic in Arizona, Scottsdale, Arizona
منابع مشابه
Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle
OBJECTIVE The contribution of mitochondrial dysfunction to skeletal muscle insulin resistance remains elusive. Comparative proteomics are being applied to generate new hypotheses in human biology and were applied here to isolated mitochondria to identify novel changes in mitochondrial protein abundance present in insulin-resistant muscle. RESEARCH DESIGN AND METHODS Mitochondria were isolated...
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تاریخ انتشار 2010